Daria

Tracy Grandstaff

Daria Morgendorffer (voice)

Wendy Hoopes

Jane Lane / Quinn Morgendorffer / Helen Morgendorffer (voice)

Julián Rebolledo

Jake Morgendorffer (voice)

Marc Thompson

Kevin Thompson (voice)

Alvaro J. Gonzalez

Trent Lane (voice)

Jessica Cydnee Jackson

Jodie Landon (voice)

Janie Mertz

Brittany Taylor / Sandi Griffin (voice)

Geoffrey Arend

Charles "Upchuck" Ruttheimer III (voice)

Sarah Drew

Stacy Rowe (voice)

John Worth Lynn, Jr.

Sick, Sad World's Announcer (voice)